Malignant hyperthermia is a rare, inherited disorder of skeletal muscle Triggered by volatile anesthetics or succinylcholine, a mutated RYR1 calcium channel stays open, flooding the cytoplasm with calcium This sustained calcium release drives nonstop actin-myosin cross-bridging, rapid ATP depletion, and massive heat production Uncontrolled hypermetabolism leads to rigidity, hyperthermia, acidosis, and rhabdomyolysis within minutes #MalignantHyperthermia #Anesthesia #RYR1 #MedTok #Anesthesiology
Malignant hyperthermia is a rare, inherited disorder of skeletal mus…
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Succinylcholine vs. Rocuronium: Key Differences, Contraindications, and Myalgia Prevention According to the Society of Critical Care Medicine (SCCM), succinylcholine is contraindicated in patients at risk for hyperkalemia, malignant hyperthermia, or certain neuromuscular disorders. In contrast, rocuronium’s primary contraindication is hypersensitivity. Succinylcholine is associated with postoperative myalgia, especially in ambulatory patients. Evidence shows that pretreatment with nondepolarizin
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