Mac & Cheese Meatloaf Casserole The ultimate comfort combo — tender, flavorful meatloaf layered with creamy mac and cheese, finished off with a crunchy golden topping. Ingredients 2 lbs ground beef (or mix of beef & pork) 1 cup breadcrumbs (panko or plain) 1 medium onion, finely diced 2 cloves garlic, minced 2 large eggs ½ cup milk ½ cup ketchup (plus extra for topping, optional) 2 tbsp Worcestershire sauce 1 tsp Italian seasoning 1 tsp salt ½ tsp black pepper 1 lb elbow macaroni 4 tbsp butter 4