Vaginal Estrogen Safety for GSM: Genitourinary Syndrome of Menopause. I wanted to talk you about some exciting news that happened this week for women dealing with Genitourinary Syndrome of Menopause, or GSM. “GSM” is a common condition that affects women in perimenopause and menopause due to low estrogen levels. GSM can cause symptoms like vaginal dryness, persistent vaginal and vulvar itching, irritation, and even bladder leakage, burning when you urinate or pee, vaginal dryness and discomfort
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