For the cell biologist, identifying changes in gene expression using DNA microarrays is just the start of a long journey from tissue to cell. We discuss how chip users can first filter noise ...

A microarray is a set of samples, for example DNA, RNA or proteins, arranged on a solid substrate or chip, such as a glass slide or silicon film, that is used in high throughput experiments.

In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...