Archives of Disease in Childhood

Learning from the past, structuring the future: using large language models to unlock a century of paediatric research in Archives of Disease in Childhood

Background and aims The centenary of Archives of Disease in Childhood ( ADC ) presents an opportunity to reflect on a century ...
eLife

Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...
eLife

Synaptic density and relative connectivity conservation maintain circuit stability across development

The authors have performed a potentially valuable new kind of analysis in connectomics, mapping to an interesting developmental problem of synaptic input to sensory neurons. While the analysis itself ...