A robust primary immune response has been correlated with the precursor number of antigen-specific T cells, as identified using peptide MHCII tetramers. However, these tetramers identify only the ...

An international team led by two Université de Montréal researchers has unveiled how a molecule capable of opening the "shell ...

Acquired immunodeficiency syndrome (AIDS) is the most advanced stage of human immunodeficiency virus (HIV) infection. At this ...

Paper in Nature Structural & Molecular Biology suggests that 21c-type antibody-eliciting vaccines will need to overcome elimination mechanisms. California Institute of Technology researchers report on ...

This is a preview. Log in through your library . Abstract Helper T-cell activation generally requires the coreceptor CD4, which binds MHC class II molecules. A remarkable feature of the CD4-MHC class ...

A 45-year-old active substance user began getting medical care in your clinic in 1997. He had started taking antiretrovirals (nelfinavir + Combivir) at another facility. Initial labs showed an ...

HIV Clin Trials. 2009;10(2):116-124. There is a risk that low, but detectable, levels of virus will not remain stable indefinitely. As VL increases, a decrease in CD4 cells can follow. Generalized ...

The major surface glycoprotein of feline immunodeficiency virus (FIV) specifically binds to a 43-kDa glycoprotein expressed on the surface of a subset of T cells in peripheral blood mononuclear cells ...

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity. The ...

People with HIV who have moderate immune suppression appear to be at greater risk of severe COVID-19 'breakthrough' infection after vaccination, according to a new study. People with HIV who have ...

Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell ...