Inflammasomes are more active in the morning than the rest of the day. Macrophage activity, which regulates inflammation, is influenced by the biologic clock in the body. A team led by Annie Curtis, ...

Endometriosis is a disease wherein tissue similar to what lines the uterus grows outside of it. The disease, which affects 10% of women of reproductive age worldwide, causes severe pain and often ...

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce ...

MEK inhibitors reduced inflammation in both macrophages and in the gut tissue of IBD patients. "IBD and other autoimmune conditions are really complex, with multiple genetic and environmental risk ...

Epstein-Barr virus infection induces the upregulation of glycolysis in intestinal macrophages, which subsequently activates Gasdermin D, NLRP3, interleukin-1β, and interleukin-18 in macrophages within ...

Chronic inflammation occurs when the immune system is stuck in attack-mode, sending cell after cell to defend and repair the body for months or even years. Diseases associated with chronic ...

Review of recent advances in biomimetic drug delivery for rheumatoid arthritis, highlighting targeted nanomedicine strategies ...

UC Santa Cruz researchers have discovered that LOUP is a multifunctional gene in immune cells called monocytes. LOUP can work inside the nucleus to control its neighbor SPI1. They also discovered that ...