Thymus is the key organ for development and maturation of T lymphocytes. The dysfunction of thymus leads to decreased immunity or autoimmune diseases. T cells can be divided intoαβ T cells and γδ T ...

T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

A hidden “jack-in-the-box” mechanism inside T cells may hold the key to unlocking more powerful cancer immunotherapies.

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack ...

Two years after this, Sakaguchi was able to link these discoveries. He proved that the Foxp3 gene governs the development of ...

French researchers have used a protein called receptor activator of NF-κB ligand (RANKL) to revive the structure and function of the thymus in old mice. The thymus sits in front of the heart and is ...

A single signaling pathway controls whether immune cells attack or befriend cells they encounter while patrolling our bodies, ...

The axolotl, a type of salamander that stays in the tadpole form throughout its life, is a master of regeneration. Axolotls ...

Paper in @jclinicalinvest (bit.ly/497z6jo) by @HopkinsMedicine @JHUMed_ID finds patient living w/ #HIV has dramatic drop in ...