Thymus is the key organ for development and maturation of T lymphocytes. The dysfunction of thymus leads to decreased immunity or autoimmune diseases. T cells can be divided intoαβ T cells and γδ T ...

Two years after this, Sakaguchi was able to link these discoveries. He proved that the Foxp3 gene governs the development of ...

The axolotl, a type of salamander that stays in the tadpole form throughout its life, is a master of regeneration. Axolotls ...

T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

French researchers have used a protein called receptor activator of NF-κB ligand (RANKL) to revive the structure and function of the thymus in old mice. The thymus sits in front of the heart and is ...

A single signaling pathway controls whether immune cells attack or befriend cells they encounter while patrolling our bodies, ...

Learn how axolotls are able to fully regenerate their thymus, a small organ that trains immune cells to fight infections.

Human peadiatric thymus image from the IBEX protein multiplex (44 proteins on the same image) platform. Thymic epithelial cells are labeled with DEC205 (cyan), pan-cytokeratin (purple), keratin 5 (red ...

Dietary restriction reshapes CD8+ T cell metabolism by increasing ketone body–driven acetyl-CoA production, preventing ...

This study provides useful insights into addressing the question of whether the prevalence of autoimmune disease could be driven by sex differences in the T cell receptor (TCR) repertoire, correlating ...

The 3-month-old girl who lives in a bubble can’t get hugs from her grandparents. Cuddling, holding and just being in the same room are off-limits too for everyone except her mother and 6-year-old ...