The development of cancer after p53 inactivation is determined by a series of genomic changes that occur in four steps. The loss of heterozygosity of TP53 (the gene encoding p53 in humans, named Trp53 ...

National Cancer Institute (NCI) dose response curves for PT162 against multiple cancers are demonstrated on the graphs Newly Patented PT162 Induces Cancer Cell Cycle Arrest and/or Apoptosis by ...

Beng Hooi Phang, Rashidah Othman, Gaelle Bougeard, Ren Hui Chia, Thierry Frebourg, Choong Leong Tang, Peh Yean Cheah, Kanaga Sabapathy Proceedings of the National Academy of Sciences of the United ...

The most commonly mutated gene in cancer, p53, works by shifting cell metabolism in a way that alters a cell’s identity, researchers at the Sloan Kettering Institute have discovered. More than 50% of ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney Kimmel ...

Role of rectal route in treating cancer pain: a randomized crossover clinical trial of oral versus rectal morphine administration in opioid-naive cancer patients with pain. The p53 gene encompasses 16 ...

Phase 0/1 of positron emission tomography (PET) imaging agent [18F]-ODS2004436 as a marker of EGFR mutation in patients with non-small cell lung cancer (NSCLC). Comparison of the tumor mutation burden ...

Since its discovery by Arnold Levine in 1979, the tumor protein p53 has transformed the field of cancer research. p53 signaling plays a key role in regulating the cell cycle, maintaining genome ...

Wistar Institute scientist Maureen Murphy wants to solve a decades-long mystery: Why is ovarian cancer often resistant to hormone therapy? In a recently published study, she shared a new theory as to ...

One of the most extensively studied genes in cancer, TP53 is well known for its role as a tumor suppressor. It senses cellular stress or damage, and in response stops cell division or initiates cell ...