Chemical libraries can be screened for small molecules that affect a variety of cellular processes including signal transduction, the cell cycle, and cellular metabolism. In particular, it may be ...

A multi-institutional research collaboration has revealed that the microtubule network (*1), which plays a vital role in cell construction and polarization (*2), utilizes the phase separation (*3) ...

Living cells depend absolutely on tubulin, a protein that forms hollow tube-like polymers, called microtubules, that form scaffolding for moving materials inside the cell. The microtubule scaffolding ...

Microtubule plus-end tracking proteins (+TIPs) play key roles in the regulation of microtubule dynamics in vivo. These proteins bind to and regulate microtubule “plus‐ends”, which are the dynamic ends ...

Microtubules are cell constituents that display several astounding properties and a unique pattern of behavior during the cell cycle. Microtubules are regulated by several proteins and complexes, and ...

Kinesin proteins eat away at microtubules, shortening them and pulling chromosomes to opposite spindle poles during cell division in most organisms. However, fission yeast lacks these proteins, and ...

Mitotic cell division, when a cell splits into two identical daughter cells, involves lots of moving parts that must be properly organized for accurate segregation. The main players responsible for ...

Almost all cell types exhibit some form of polarity; cell polarity refers to the spatial differences in shape, structure and function within a cell, which enables the cell to carry out specialized ...

Microtubule-targeting agents impact microtubule dynamics to induce mitotic arrest and tumor cell death. Tubulin is therefore a relevant target for the discovery of new agents acting as tumor ...

Living cells depend absolutely on microtubules that form a scaffolding for moving materials inside the cell. Microtubule fibers are hollow rods made of much smaller tubulin subunits that spontaneously ...