The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing ...

Treatment of rheumatoid arthritis (RA) has evolved from the use of conventional treatments, such as methotrexate, to disease-modifying biologic agents that can slow the disease process and make ...

Interleukins form a large group of cell signaling molecules within the cytokine family. They were first described as proteins that were produced by and acted on leukocytes. It has become clear that ...

Acute kidney injury (AKI) is a severe renal disorder affecting approximately 10%–15% of hospitalized patients and up to 50% in intensive care units (ICUs). Its pathogenesis involves complex ...

Scientists have made an important breakthrough in understanding how inflammation is regulated. They have just discovered that a key immune alarm protein previously believed to calm down the immune ...

"Why there are so many interleukins that bind to the same receptor is a mystery, but if we were to speculate it may be because this receptor serves a very important sentinel function in our skin, and ...

Scientists from Trinity College Dublin have made an important breakthrough in understanding how inflammation is regulated. They have just discovered that a key immune alarm protein previously believed ...