Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

WASHINGTON -- Neurodegenerative diseases such as Alzheimer's and Parkinson's are often accompanied by amyloid proteins in the brain that have become clumped or misfolded. A newly developed technique ...

(a) Single-molecule localization microscopy of a network of amyloid aggregates. (b) Nile red binding orientations to amyloid surfaces. (c-g) Individual orientation measurements along fibril backbones ...

Neurodegenerative diseases such as Parkinson’s and Alzheimer’s are accompanied by amyloid proteins that have been misfolded. However, the mechanism by which protein misfolding and aggregation trigger ...

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein. A member of the RNA-associated ...

Though there is so much to learn about the way Alzheimer's develops in the human brain, amyloid beta proteins have long been implicated in its advance. A new study has uncovered a previously unknown ...

For the first time, scientists have described the structure of an endogenously sourced, functioning neuronal amyloid at atomic resolution. The amyloid is composed of self-aggregated Orb2, the fruit ...

Lauren E. Buchanan, Joshua K. Carra, Aaron M. Fluitt, Andrew J. Hoganson, Sean D. Moran, Juan J. de Pablo, James L. Skinner, Martin T. Zanni Proceedings of the ...

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein. A member of the RNA-associated ...

A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer's disease patients. If perfected in humans ...