This is a preview. Log in through your library . Abstract Small heat shock protein HSPB7 is highly expressed in the heart. Several mutations within HSPB7 are associated with dilated cardiomyopathy and ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 24 (June 11, 2019), pp. 12084-12093 (10 pages) Srv2p/CAP1 is an essential regulator of actin turnover, ...

Supercomputer simulations allocated by XSEDE on TACC's Stampede2 have helped solve the mystery of how actin filaments polymerize. Researchers employed all-atom molecular dynamics to show structural ...

The dynamic processes that occur during the growth of actin, via polymerization, and the breakdown of actin both play significant roles in cellular mechanisms like migration and adhesion. Due to the ...

Actin filaments — protein structures critical to living movement from single cells to animals — have long been known to have polarity associated with their physical characteristics, with growing ...

Many cells in our body constantly change their shape and move within our tissues. For example, wound healing and the immune system depend on migrating cells. On the other hand, uncontrolled cell ...

Two specific proteins take apart the cell's actin filaments at one end and return the building blocks to the other end for a new round of polymerization. The structure of this machinery driving cell ...

How can a nanometer-scale protein generate and transmit forces to control cell shape changes across micrometer-scale distances? A crawling cell pushes its plasma membrane forward. The protein is actin ...

Actin cytoskeleton is essential for eukaryotic cells. To exert its countless cellular functions, actin undergoes dynamic remodeling orchestrated by the large number of actin-interacting factors.

Brown scientists have described a previously unknown but critical blood-clotting role for Arp2/3, a complex of seven proteins found in animal and plant cells. Reporting in the June 15 issue of Blood, ...