This is a 3-D computer model of the serotonin 5-HT3 receptor, embedded through a lipid bilayer membrane (horizontal structure with black lines and yellow balls) as it would be naturally in a cell.

This is a 3-D computer model of the serotonin 5-HT3 receptor, embedded through a lipid bilayer membrane (horizontal structure with black lines and yellow balls) as it would be naturally in a cell.

Purpose: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy ...

Clinical applications of hematopoietic growth factors. Comparison data used are the preclinical pharmacology as well as the design and results of clinical trials. Seven comparative studies that used ...

Heron Therapeutics, Inc. (HRTX) today announced positive, top-line results from its recently completed Phase 3 MAGIC study. MAGIC evaluated the efficacy and safety of the Company's 5-HT3 receptor ...

In ferrets, the selective 5-hydroxytryptamine (5-HT) 5-HT3 receptor antagonist BRL 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg ...