This is a 3-D computer model of the serotonin 5-HT3 receptor, embedded through a lipid bilayer membrane (horizontal structure with black lines and yellow balls) as it would be naturally in a cell.

Clinical applications of hematopoietic growth factors. Comparison data used are the preclinical pharmacology as well as the design and results of clinical trials. Seven comparative studies that used ...

Although brainstem serotonergic (5-HT) systems are involved in the protective responses to hypoxia, abnormalities of 5-HT function are strongly implicated in SIDS, and the neurochemical mechanisms by ...

This is a 3-D computer model of the serotonin 5-HT3 receptor, embedded through a lipid bilayer membrane (horizontal structure with black lines and yellow balls) as it would be naturally in a cell.

Purpose: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy ...

In ferrets, the selective 5-hydroxytryptamine (5-HT) 5-HT3 receptor antagonist BRL 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg ...

Primary prophylaxis of febrile neutropenia using long-acting granulocyte colony-stimulating factors in female patients receiving dose-dense biweekly chemotherapy in the clinical routine. This is an ...

Heron Therapeutics, Inc. (HRTX) today announced positive, top-line results from its recently completed Phase 3 MAGIC study. MAGIC evaluated the efficacy and safety of the Company's 5-HT3 receptor ...

The FDA has approved Varubi for use in combination with other antiemetic agents to prevent delayed chemotherapy-induced nausea and vomiting from initial and repeat chemotherapy regimens, including ...

Scientists have elucidated for the first time how a notoriously elusive serotonin receptor functions with atom-level detail. The receptor transmits electrical signals in neurons and is involved in ...