After acute injury to the brain, neurons at the damage epicentre depolarize, and this depression of activity spreads outward in waves through the cortex. A recently published study sheds light on how ...

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Membrane depolarization activates voltage-dependent Ca²⁺ channels (VDCCs) inducing Ca²⁺ release via ryanodine receptors (RyRs), which is obligatory for skeletal and cardiac muscle contraction and ...

A 2018 study may lend credence to what happens during the biological and irreversible death of the brain organ. Published in the Annals of Neurology, the study inspected spreading depolarization of ...

People with temporal lobe epilepsy in particular often wander around aimlessly and unconsciously after a seizure. Researchers at the University Hospital Bonn (UKB), the University of Bonn, and the ...