Bacteria that have sustained long-standing close associations with eukaryotic hosts have evolved specific adaptations to survive and replicate in this environment. Perhaps one of the most remarkable ...

Many gram-negative pathogens use a 'needle-like' T3S machinery as a molecular weapon to deliver effectors directly into target cells 1,2. Contact of the T3S system needle tip with cholesterol-rich ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 25 (June 22, 2010), pp. 11295-11300 (6 pages) Flagella are the bacterial organelles of motility and can ...

Type III protein secretion systems are essential virulence factors for many important pathogenic bacteria. The entire protein secretion machine is composed of several substructures that organize into ...

Cryo-electron microscopic reconstruction of the antigen binding region of a human antibody (yellow) to the needle tip complex (blue) of the type III secretion system of Pseudomonas aeruginosa.

Protein production is a multi-billion dollar industry, with applications in pharmaceuticals, industrial enzyme use (eg in laundry detergent), and biomaterials. Bacteria are receiving renewed interest ...

MassGeneral Hospital for Children (MGHfC) has been named a Grand Challenges Explorations winner through an initiative funded by the Bill & Melinda Gates Foundation. Led by Alessio Fasano, MD, MGHfC ...

Scientists have discovered that erucamide, a plant-produced fatty acid amide, disrupts the function of the bacterial injectosome—a syringe-like nanomachine that some pathogenic bacteria use to help ...