In a recent online publication in SCIENCE CHINA Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of ...
The enzyme activation-induced cytidine deaminase (AID) is central to the diversification of antibodies in B cells. By converting cytosine to uracil within single-stranded DNA, AID initiates somatic ...
Nanopore sequencing offers comparable accuracy to short-read NGS for IGH clonotyping in CLL, with advantages in cost and laboratory footprint. The study confirms reliable somatic hypermutation status ...
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