Figure 3: Various scaffolds utilized to engineer binders to Ras and their binding epitopes. Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated ...
Relapses in a common form of leukemia may be preventable following new research that has identified how the cancer develops resistance to first line treatments. Relapses in a common form of leukemia ...
National Institutes of Health (NIH) scientists and collaborators say they have discovered a new way in which RAS genes, commonly mutated in cancer, may drive tumor growth beyond their well-known role ...
Find a tumor in a human or rodent, and the chances are that lurking within it will be an activated ras gene. The cancer-police have been trailing it for the better part of two decades and the file of ...
Researchers around the world are studying how the human brain achieves its extraordinary complexity. A team at the Central Institute of Mental Health in Mannheim and the German Primate Center—Leibniz ...
Testing older potential organ donors for dangerous "zombie" cells could help to increase the number of hearts available for transplant, according to research presented at the British Cardiovascular ...
The signal recognition particle (SRP)-mediated translocation of proteins across the RER is a GTP dependent process. Analysis of the primary amino acid sequence of one protein subunit of SRP (SRP54), ...
When loaded alongside GTP-γ-S into ATP-permeabilized cells, neomycin, at concentrations below 1 mM, inhibits GTP-γ-S-induced histamine secretion and phosphatidic acid formation. However, at higher ...
Two original papers in Nature highlight the discovery and translational implications of RMC-7977, a RAS(ON) multi-selective tri-complex inhibitor that exhibits unprecedented anti-tumor activity in ...
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