Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular process ...

The utility of long reads is well documented in studying complex genomic regions, structural variation, epigenetic modifications, and transcriptomics. More specifically, long read data are increasing ...

Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled over ...

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.

In TDP-43 proteinopathies, such as frontotemporal dementia, amyotrophic lateral sclerosis, and limbic predominant age-related TDP-43 encephalopathy, the notorious RNA binding protein abandons its post ...