Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota. However, the underlying mechanisms ...

I have a patient with gallstones. His alkaline phosphatase is 1800 (probably due to stones in the common bile duct [CBD]) and bilirubin is normal. What would be the best approach for management of ...

Gut microbiota produce trimethylamine, which enters the liver via the portal circulation and is primarily oxidized by FMO3 to produce TMAO. TMAO upregulates hepatic PCSK9 gene expression while ...

The gallbladder is a small, grape sized, organ attached to the digestive tract. It secretes a fluid called bile into it in response to a meal. Bile emulsifies dietary fats by increasing their exposure ...

A new study published in the journal Gut has shed light on the complex relationship between serum lipids, lipid-modifying targets, and cholelithiasis, a common condition characterized by the formation ...

Right-side abdominal pain after eating can signal gallstones, liver infection, ulcers or indigestion. Doctor explain causes, ...