This meta-analysis included 8881 patients treated for opioid-induced constipation. Drug treatment was associated with lower risk of failure to respond to therapy than placebo. Commonly observed ...

Peripherally acting mu-opioid antagonists (PAMORA). PAMORAs indicated for the treatment of OIC include naloxegol, naldemedine, and methylnatrexone. These agents are opioid antagonists selective to ...

Symproic significantly improved bowel function and frequency of spontaneous bowel movements in patients receiving opioids compared to placebo. The study highlighted a 47.6% difference in bowel ...

At this year’s PAINWeek Conference in Las Vegas, Salix Pharmaceuticals sponsored an interactive product theater panel to discuss the challenges associated with OIC in clinical practice, how to address ...

PALM SPRINGS, California — A peripherally acting oral μ-opioid receptor antagonist is superior to placebo in treating opioid-induced constipation (OIC) and doesn't reduce the analgesic effect of ...

Pharmacology: The use of opioid analgesics can lead to constipation due to their effect on intestinal smooth muscle and their interference with the bowel’s normal elimination function.

Medically reviewed by Femi Aremu, PharmD Key Takeaways Opioids can cause opioid-induced constipation by slowing down digestion and reducing fluid in the intestines.NSAIDs like ibuprofen can irritate ...

About 9-12 million Americans suffer from chronic pain annually, and most are prescribed opioid medications to treat and control their symptoms 1. While opioids can help relieve and manage chronic pain ...

Salix Pharmaceuticals has launched the first connected TV commercial for its opioid-induced constipation drug Relistor and is relying on an unusual, animated character to help lead the push. The new ...