The penultimate week of the 2025 NFL regular season is here. USA TODAY Sports provides the early predictions for Week 17.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The 2025-26 NFL regular season is heading into the last few weeks, and Week 16 saw one of the wildest set of games in recent memory from the two-point conversion that helped the Seattle Seahawks beat the Los Angeles Rams on Thursday night to the Chicago Bears' improbable comeback win on Saturday night to whatever happened at the end of that

With one game left to go in NFL Week 17 action, we know 12 of the 14 teams that will be advancing to the postseason.