Genome editing is a powerful biotechnology tool that allows scientists to make precise changes to an organism's DNA. It involves the use of specialized enzymes, known as engineered nucleases or ...

A committee-supported project or activity that has been completed and for which output dissemination has begun. Its committee has been disbanded and closeout procedures are underway. An ad hoc ...

The prime editor is a fusion protein consisting of a catalytically impaired Cas9 nickase (Cas9n) and an engineered reverse transcriptase (RT). The Cas9n is guided by a prime editing guide RNA (pegRNA) ...

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...

Study reveals that evolutionary divergence occurred before ecological divergence, enabling these insects to feed on both wood and soil. Future discoveries may be applied to the production of biofuels.

Genetic regulation of glucose homeostasis is central to the maintenance of human health and the prevention of metabolic disorders such as type 1 and type 2 diabetes. Recent advances in molecular ...

A team of Chinese researchers has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August ...

Researchers have determined whether a specific chemical modification of a protein that packages the genome called a histone affects gene activity and cell proliferation. Researchers have determined ...

Over millennia, there has been a seamless continuum of technologies for genetic modification of plants, animals, and microorganisms, with progressive improvements in precision and predictability – a ...

The discovery of CRISPR-Cas9’s gene-editing prowess revolutionized genetic engineering just over a decade ago. Now it appears that genetic engineering technology may be taking its next big leap.

An ad hoc committee appointed by the National Academies to explore heritable genetic modifications of food animals. This committee will address methods for heritable genetic modifications and identify ...