New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...

MINNEAPOLIS/ST. PAUL — New research led by the University of Minnesota Medical School demonstrates that molecules acting as “molecular bumpers” and “molecular glues” can rewire G protein-coupled ...

Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...

The most important class of drug discovery targets today is undoubtedly the class of G-protein coupled receptors (GPCRs). These receptors account for more than 30% of all targets currently under ...

The GPCR-targeting therapies market is expected to grow significantly in the coming years. This is due to the increasing number of patients who are being diagnosed with cancer, the growing awareness ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). Subscribe to our newsletter ...