This study illustrates how persistent mRNA rG4 structures induce ribosome pausing and collisions, leading to proteostasis collapse in senescent cells. The RNA helicase DHX9 acts as a key regulator, ...

Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these ...

ADAR1 Zβ bound to a G-quadruplex. RNA editing by ADAR1 improves the performance of the DNA repair protein NEIL1. Recoding is likely facilitated by the G-quadruplex that localizes ADAR1 to this site.

Researchers from Aarhus University and the Italian Institute of Technology have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have ...

(a) Fluorescence images showing the chromatin in FGO stained with DAPI. Scale bar, 20 μm. Yellow triangles indicate DAPI-dense heterochromatin foci and the red triangles denote the nucleoli or NLBs.

RNA transcription is the genomic process in which a cell produces a duplicate of a gene’s DNA sequence. Present in both DNA and RNA sequences, a G-quadruplex (GQ) is a structure of four guanine bases ...