New research from the University of Maryland and the National Institutes of Health reveals a new role for the enzyme telomerase. Telomerase's only known role in normal tissue was to protect certain ...
In an effort to understand and control telomerase activity, researchers have discovered a protein "motif," named TFLY, which is crucial to the function of telomerase. Altering this motif disrupts ...
Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...
Telomerase contains a large RNA subunit, TER, and a protein catalytic subunit, TERT. Whether telomerase functions as a monomer or dimer has been a matter of debate. Here we report biochemical and ...
Of the many components in the cell thought to play a role in cancer, few have received more attention in recent years than an enzyme that has been dubbed a cellular fountain of youth. Known as ...
It is difficult to underestimate the importance of telomerase, an enzyme that is the hallmark of both aging and the uncontrolled cell division associated with cancer. In an effort to understand and ...
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Scientists find key protein problem behind dangerous telomere diseases
Researchers uncover a crucial hidden function of the protein RPA, revealing how its failure to activate telomerase leads to ...
MENLO PARK, Calif.--(BUSINESS WIRE)--Geron Corporation (Nasdaq:GERN) today announced the publication of preclinical data on TAT2, a small molecule telomerase activator. The studies show that human CD8 ...
Researchers at UC Santa Cruz have determined the structure of a key part of the enzyme telomerase, which is active in most cancers and enables cancer cells to proliferate indefinitely. The new ...
"We have very deep insights into how telomerase works and how the components work together," Susac said. "Each of these interactions could be a point to target, and possibly disrupt or enhance the ...
Telomerase promotes proliferation of resting stem cells through a mechanism that does not involve the extension of chromosomal telomeres, researchers report in Nature this week. "This is a completely ...
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