A better way to detect off-target genome changes from base editors

Scientists and physicians can better assess precision genome editing technology using a new method made public today by St.
GEN

Base Editor Converts “Wanted” Cs, Spares “Bystander” Cs

“Round up the usual suspects!” This expression, which bespeaks expediency, could apply to the gene editing tools known as cytosine base editors (CBEs). CBEs, which are supposed to convert selected ...
GEN

CRISPR Base Editor Repairs Faulty Genes in Cystic Fibrosis Organoids

Ordinarily, CRISPR-Cas9 gene editing systems cut all the way across double-stranded DNA. But these systems can be modified so that they inflict nothing more drastic than a nick. The advantage of a ...
The Scientist

MOBE: A Base Editor That Multitasks without Mix-ups

A single mutation in a person’s genome can be the difference between health and disease, and with base editing, researchers can recreate these mutations in a laboratory to study how genetic changes ...
C&EN

2-in-1 base editors make two DNA edits at once

At least five groups have independently invented a new class of CRISPR gene editing tools called dual base editors. The systems combine the functions and components of two CRISPR base editors, which ...
EurekAlert!

Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-to-K base editing in rice plants

Beijing Zhongke Journal Publising Co. Ltd. This study is led by Professor Lanqin Xia (Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China). The authors isolated a rice ...