One-letter difference in our DNA determines whether BCG vaccine provides good protection against tuberculosis or not. Researchers have elucidated how that one letter difference affects the activation ...

RNA’s Surprising Role in DNA Repair New insights could lead to improved treatments for cancer and other diseases. Francesca Storici and her research team discovered a surprising role for RNA in DNA ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

This image depicts the chemical structure of cytosine. It shows a hexagonal ring with nitrogen atoms at positions 1 and 3, and a primary amine group attached to carbon 4. The two remaining positions ...

In a recent study in Nature Communications, researchers examined the adenosine-to-inosine (A-to-I) nucleoside editing of postmortem and live prefrontal cortical tissues. Researchers found that RNA ...

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...

This image illustrates the chemical structure of a purine molecule, highlighting the numbering of the carbon and nitrogen atoms. The purine structure consists of a pyrimidine ring (positions 1 to 6) ...

A research group at the Italian Institute of Technology (Istituto Italiano di Tecnologia - IIT) has identified a candidate molecule that could improve current therapies against pancreatic cancer. The ...