Cell signalling pathways are central to maintaining cellular homeostasis and regulating essential functions such as proliferation, apoptosis, and repair. In both cancer and neurodegenerative diseases, ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on ...

Cancer-fighting T cells do not simply "run out of energy." They are molecularly reprogrammed. For years, mitochondrial ...

Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, largely due to metastasis and ...

SMART, a new software package, can make studying signaling processes significantly easier. Results could accelerate research in fields across the life sciences, such as systems biology, pharmacology ...

Researchers have uncovered a surprising molecular chain reaction in the brain that may play a role in some forms of autism. The study suggests that nitric oxide, a tiny signaling molecule normally ...

Inositol phosphates are crucial secondary messengers that modulate a wide range of cellular processes, from energy metabolism to gene expression. These molecules, particularly inositol pyrophosphates, ...

In a recently published review, a research team led by MedUni Vienna has highlighted a promising new approach to drug discovery. The focus is on the targeted modulation of certain intracellular ...

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns. Scientists at St. Jude Children's ...

Severe bacterial pneumonia remains a major cause of death in critically ill patients, largely due to impaired early immune responses. New research reveals that butyric acid, a metabolite produced by ...

Background High serum levels of interleukin 6 (IL-6) predict poor prognosis in intrahepatic cholangiocarcinoma (iCCA), a ...