Research into cell cycle regulation and size control in microorganisms has yielded a nuanced understanding of how these entities maintain homeostasis and synchronise growth with division. In both ...

The regulation of the cell cycle is a fundamental process ensuring the accurate replication and division of cells. Central to this regulation are the Cdc25 phosphatases, which activate ...

TGFβ/ACTIVIN-SMAD2/3-EZH2 cooperates with OCT4 and NANOG in self-renewing hPSCs to keep CDKIs in an epigenetically poised state for rapid activation. Upon the initiation of endoderm differentiation ...

The presented findings are important for the field of cell-cycle control. They provide new insights into the origin of cell size variability in budding yeast. The strength of evidence is solid.

Arteriovenous malformations, a hallmark of hereditary hemorrhagic telangiectasia, may be driven by endothelial cell-cycle acceleration via CDK6, suggesting potential for repurposing CDK6 inhibitors.