New NE-AFM method measures nuclear stiffness in living cells. It shows cancer nuclei change softness with chromatin and environment, aiding diagnosis and treatment. By employing a technique called ...

Neuroblastoma cancer cells before (left) and after (right) chemotherapy. The black threads are the cell's internal scaffolding, which breaks apart during treatment. This damage should kill the cell, ...

(a) A scanning electron microscope (SEM) image of the nanoneedle probe used for the measurements. (b) Elasticity map of a 1 µm × 1 µm area on the nuclear surface, showing the change in elasticity ...