The elaboration of an efficient immune response against pathogens involves complex intracellular antigen-processing events. Endogenous antigens such as viral proteins synthesized by infected host ...
To better understand the generation of MHC class l-associated peptides, we used a model antigenic protein whose proteasomemediated degradation is rapidly and reversibly controlled by Shield-1, a ...
EMERYVILLE, Calif., Feb. 27, 2019 (GLOBE NEWSWIRE) -- Gritstone Oncology, Inc. (Nasdaq:GRTS), a clinical-stage biotechnology company developing the next generation of cancer immunotherapies to fight ...
The major histocompatibility complex (MHC) is a group of genes that encode proteins on the cell surface that have an important role in immune response. Their main role is in antigen presentation where ...
Many cancers evade immune rejection by suppressing major histocompatibility class I (MHC-I) antigen processing and presentation (AgPP). Such cancers do not respond to immune checkpoint inhibitor ...
Figure 1: Activated pDCs are powerful activators of allogeneic CD8 + T cells. Figure 2: The pDCs cross-present influenza virus antigen more rapidly and efficiently than do mDCs. Figure 3: MHC class I ...
Background: We have shown that the high prevalence of HLA-A2 in Scandinavia is associated to poor prognosis in advanced (stage III-IV) serous adenocarcinoma of the ovary. Our objective was to analyse ...
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