ATP-binding cassette (ABC) transporters represent a vital family of membrane proteins that utilise the energy of ATP hydrolysis to transport a diverse array of substrates across cellular membranes.

A former Vertex scientist is setting his sights on an entire family of transporter proteins that can cause scores of rare inherited conditions. His startup, Rectify Pharmaceuticals, recently completed ...

(MEMPHIS, Tenn. – December 5, 2025) When a cell receives a message from outside, it generates a molecule called cyclic AMP (cAMP) to relay this message. To ensure the signal reaches the correct ...

ATP-binding cassette (ABC) transporters are transmembrane proteins essential for the biliary secretion of bilirubin, bile acids, phospholipids, and ...

Transport proteins are responsible for the ongoing movement of substrates into and out of a biological cell. However, it is difficult to determine which substrates a specific protein can transport.